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M7782

Sigma-Aldrich

Antiflammin-1

≥97% (HPLC)

Synonym(s):

Anti-inflammatory peptide 1, Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser

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About This Item

Empirical Formula (Hill Notation):
C45H82N12O14S2
CAS Number:
118850-71-8
Molecular Weight:
1079.33
MDL number:
MFCD00076844
UNSPSC Code:
12352200

assay

≥97% (HPLC)

composition

Peptide content, ~70%

storage temp.

−20°C

SMILES string

CSCCC(N)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(O)=O

Biochem/physiol Actions

Inhibits synthesis of platelet activating factor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David B Rivers et al.
Toxicon : official journal of the International Society on Toxinology, 40(1), 9-21 (2001-10-17)
The mode of action of venom from the ectoparasitic wasp Nasonia vitripennis in eliciting cell death was examined using an in vitro approach with BTI-TN-5B1-4 cells, and the cell responses were compared to those evoked by the extensively studied wasp
Jianzhong Han et al.
Cell biology international, 32(9), 1108-1115 (2008-06-11)
Antiflammin-1 (AF-1) is a synthetic nonapeptide with a similar sequence to the conserved sequence of CC10 secreted by lung Clara cells. Studies suggest that it is potent inhibitor of inflammation. We investigated the effects and possible mechanisms of AF-1 on
N K Mize et al.
Experimental dermatology, 6(4), 181-185 (1997-08-01)
The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation
M Marastoni et al.
Arzneimittel-Forschung, 41(3), 240-243 (1991-03-01)
The nonapeptide H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH (antiflammin), corresponding to a high amino acid similarity region of uteroglobin was prepared by solution and solid phase synthesis. The peptide do not inhibit pancreatic phospholipase A2 in vitro and the carrageenin-induced oedema in vivo.
Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions.
G Camussi et al.
Advances in experimental medicine and biology, 279, 161-172 (1990-01-01)
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