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M0132

Sigma-Aldrich

5-Methyltetrahydrofolic acid disodium salt

≥88% (UV-vis)

Synonym(s):

5-Methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid disodium salt, 5-Methyl-THF

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About This Item

Empirical Formula (Hill Notation):
C20H23N7Na2O6
CAS Number:
68792-52-9
Molecular Weight:
503.42
MDL number:
MFCD00070147
UNSPSC Code:
12352204
PubChem Substance ID:
24896534
NACRES:
NA.32
Pricing and availability is not currently available.

assay

≥88% (UV-vis)

form

powder

solubility

water: 25 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].CN1C(CNc2ccc(cc2)C(=O)N[C@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H25N7O6.2Na/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;;/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31);;/q;2*+1/p-2

InChI key

KKIWVYLOTHCGRV-UHFFFAOYSA-L

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Biochem/physiol Actions

5-Methyl-THF acts as both cofactor and substrate in the regeneration of methionine from homocysteine through the action of 5-methyl-THF-homocysteine S-methyltransferase.

Packaging

Sealed ampule

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000429910
0000429909
0000429909
0000429910
0000387734

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Sharareh Rezaeian et al.
International journal of medicinal mushrooms, 23(2), 57-66 (2021-02-28)
Edible mushrooms are among food sources containing natural folate compounds. However, little is known about how the content of folates in edible mushrooms may be improved. This study aimed to enrich Flammulina velutipes with higher levels of folates and to
Joachim Michael Matz et al.
Cell reports, 26(2), 356-363 (2019-01-10)
Folate metabolism is essential for DNA synthesis and a validated drug target in fast-growing cell populations, including tumors and malaria parasites. Genome data suggest that Plasmodium has retained its capacity to generate folates de novo. However, the metabolic plasticity of

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