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L7154

Sigma-Aldrich

[Hyp9]-LH-RH

≥97% (HPLC)

Synonym(s):

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Hyp-Gly-NH2

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About This Item

Empirical Formula (Hill Notation):
C55H75N17O14
CAS Number:
67019-13-0
Molecular Weight:
1198.29
MDL number:
MFCD00214314
UNSPSC Code:
12352200
PubChem Substance ID:
24896454

assay

≥97% (HPLC)

UniProt accession no.

P20068

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc4cnc[nH]4)NC(=O)C5CCC(=O)N5)C(=O)NC(CCCNC(N)=N)C(=O)N6CC(O)CC6C(=O)NCC(N)=O

InChI

1S/C55H75N17O14/c1-28(2)16-38(49(81)67-37(8-5-15-60-55(57)58)54(86)72-25-33(75)20-43(72)53(85)62-23-44(56)76)66-46(78)24-63-47(79)39(17-29-9-11-32(74)12-10-29)68-52(84)42(26-73)71-50(82)40(18-30-21-61-35-7-4-3-6-34(30)35)69-51(83)41(19-31-22-59-27-64-31)70-48(80)36-13-14-45(77)65-36/h3-4,6-7,9-12,21-22,27-28,33,36-43,61,73-75H,5,8,13-20,23-26H2,1-2H3,(H2,56,76)(H,59,64)(H,62,85)(H,63,79)(H,65,77)(H,66,78)(H,67,81)(H,68,84)(H,69,83)(H,70,80)(H,71,82)(H4,57,58,60)

InChI key

IFKVSSKFSAFSGI-UHFFFAOYSA-N

Gene Information

rat ... Nts(299757)

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
024H03682
024H03681

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J P Gautron et al.
Molecular and cellular endocrinology, 110(1-2), 161-173 (1995-04-28)
[Hydroxyproline9]luteinizing hormone-releasing hormone ([Hyp9]LHRH), an endogenous hydroxylated post-translational product of the LHRH sequence, has been isolated from mammalian hypothalamus. Using the LHRH-hypothalamic cell line (GT1-7) of fetal origin, we attempted to define the substrates available for the hydroxylation process during
J P Gautron et al.
Molecular and cellular endocrinology, 85(1-2), 99-107 (1992-05-01)
In vitro and in vivo release of pituitary hormones were studied in the presence of (hydroxyproline9)LHRH ((Hyp)LHRH), a newly characterized endogenous molecular form of LHRH. Results were compared to those obtained with LHRH itself. (Hyp)LHRH, as LHRH, stimulated both luteinizing
L Rochdi et al.
Journal of neuroendocrinology, 12(9), 919-926 (2000-09-06)
The differential secretion of gonadotropin-releasing hormone (GnRH) and [hydroxyproline9]GnRH (HypGnRH) has been recently reported from the adult rat hypothalamus. We report here in vitro cosecretion of HypGnRH and GnRH by the hypothalamus of 2-45 day-old-rats and provide evidence that they
J P Gautron et al.
Neuroendocrinology, 58(2), 240-250 (1993-08-01)
Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of
J P Gautron et al.
Biochemical and biophysical research communications, 189(3), 1368-1373 (1992-12-30)
A naturally occurring analog of the decapeptide luteinizing hormone-releasing hormone ([Hyp9]LHRH) has been described previously in the hypothalamus of several mammals. It derives from post-translational hydroxylation of the LHRH proline9 residue. In the present work, intermediate LHRH precursors exhibiting both
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