Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

L4420

Sigma-Aldrich

LY-367385 hydrochloride

≥98% (HPLC)

Synonym(s):

(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$88.40
25 MG
$335.00

$88.40

Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$88.40
25 MG
$335.00

About This Item

Empirical Formula (Hill Notation):
C10H11NO4 ·HCl
CAS Number:
198419-91-9
Molecular Weight:
245.66
MDL number:
MFCD02262124
UNSPSC Code:
12352200
PubChem Substance ID:
329817409
NACRES:
NA.77

$88.40

Check Cart for Availability
Request a Bulk Order

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H2O: >10 mg/mL

originator

Eli Lilly

storage temp.

room temp

SMILES string

Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O

InChI

1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChI key

SGIKDIUCJAUSRD-QMMMGPOBSA-N

Application

LY-367385 hydrochloride has been used as a non-N-methyl-D-aspartate (NMDA) glutamate receptor blocker in neuronal stimulation experiment.[1]

Biochem/physiol Actions

LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).[2]
LY-367385 is a selective metabotropic glutamate 1a receptor (mGlu1a) antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000268199
0000268198
0000263771
030M4746V
030M4731V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

D Y Sakae et al.
Molecular psychiatry, 20(11), 1448-1459 (2015-08-05)
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each
Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
Bonsi P, et al.
Neuropharmacology, 49(5), 104-113 (2005)
Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
Lautz JD, et al.
Journal of Neurochemistry, 146(5), 540-559 (2018)
Miseon Kang et al.
Scientific reports, 10(1), 17921-17921 (2020-10-23)
Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable AMPA receptor (CP-AMPAR) as major
Hanne Mette Hoffmann et al.
The international journal of neuropsychopharmacology, 20(1), 72-82 (2016-10-17)
Cocaine addiction continues to be a major heath concern, and despite public health intervention there is a lack of efficient pharmacological treatment options. A newly identified potential target are the group I metabotropic glutamate receptors, with allosteric modulators showing particular
View All Related Papers

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service