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K4389

Sigma-Aldrich

KR-32568

≥98% (HPLC), solid

Synonym(s):

[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine

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5 MG
$243.00
25 MG
$885.00

$243.00

Estimated to ship onMay 04, 2025

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5 MG
$243.00
25 MG
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About This Item

Empirical Formula (Hill Notation):
C13H12FN3O2
CAS Number:
852146-73-7
Molecular Weight:
261.25
MDL number:
MFCD08705324
UNSPSC Code:
12352200
PubChem Substance ID:
24724522
NACRES:
NA.77

$243.00

Estimated to ship onMay 04, 2025

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~10 mg/mL

storage temp.

2-8°C

SMILES string

Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N

InChI

1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)

InChI key

DTLDHYBZLVASJQ-UHFFFAOYSA-N

Gene Information

human ... SLC9A1(6548)

Biochem/physiol Actions

Sodium/hydrogen exchanger-1 (NHE-1) inhibitor.
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
056K46012
056K46011
056K4601

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Daniele Torella et al.
Journal of the American Heart Association, 3(2), e000434-e000434 (2014-03-29)
Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role in the diabetic cardiomyopathy is still unknown. We obtained left ventricular samples

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