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K2139

Sigma-Aldrich

K-252b solution

≥98% (HPLC), from Nonomuraea longicatena, ready-to-use solution

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About This Item

Empirical Formula (Hill Notation):
C26H19N3O5
CAS Number:
99570-78-2
Molecular Weight:
453.45
MDL number:
MFCD27976629
UNSPSC Code:
12352200
PubChem Substance ID:
329817133

biological source

Nonomuraea longicatena

assay

≥98% (HPLC)

form

ready-to-use solution

concentration

1 mM in DMSO

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H][C@]1(C[C@]2(O)C(O)=O)O[C@]2(C)N3C4=C(C=CC=C4)C5=C3C(N1C6=C7C=CC=C6)=C7C8=C5CNC8=O

InChI

1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1

InChI key

AMSOPBXQXSAAAC-PLZPTFKGSA-N

Biochem/physiol Actions

Non-selective protein kinase inhibitor; ecto-protein kinase inhibitor; PKC inhibitor

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F

flash_point_c

87 °C

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Certificates of Analysis (COA)

Lot/Batch Number
022M4137
14111013
040M4053
048K4123
055K4119

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S Fujii et al.
Neuroscience, 113(3), 617-628 (2002-08-02)
The mechanism of ATP-induced long-term potentiation (LTP) was studied pharmacologically using guinea-pig hippocampal slices. LTP, induced in CA1 neurons by 10 min application of 10 microM ATP, was blocked by co-application of the N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (5 or
Luis Cartuche et al.
Biomolecules, 10(4) (2020-04-30)
Chagas disease and leishmaniasis are neglected tropical diseases caused by kinetoplastid parasites of Trypanosoma and Leishmania genera that affect poor and remote populations in developing countries. These parasites share similar complex life cycles and modes of infection. It has been

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