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K1519

Sigma-Aldrich

KM11060

≥98% (HPLC)

Synonym(s):

7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

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About This Item

Empirical Formula (Hill Notation):
C19H17Cl2N3O2S
CAS Number:
774549-97-2
Molecular Weight:
422.33
MDL number:
MFCD01524977
UNSPSC Code:
12352200
PubChem Substance ID:
329817126

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL

storage temp.

room temp

SMILES string

Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccnc4cc(Cl)ccc34

InChI

1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2

InChI key

GIEHIZKCIZLXLF-UHFFFAOYSA-N

Biochem/physiol Actions

KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Caiqi Zhao et al.
PloS one, 8(12), e82683-e82683 (2013-12-25)
Mutation of CFTR (cystic fibrosis transmembrane conductance regulator) leads to cystic fibrosis (CF). Patients with CF develop abnormalities of blood platelets and recurrent lung inflammation. However, whether CFTR-mutated platelets play a role in the development of lung inflammation is elusive.

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