Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

I1759

Sigma-Aldrich

Isosorbide dinitrate

powder

Synonym(s):

ISDN

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C6H8N2O8
CAS Number:
87-33-2
Molecular Weight:
236.14
MDL number:
MFCD00868238
UNSPSC Code:
12352200
PubChem Substance ID:
24895946

form

powder

contains

~60% lactose

color

white

solubility

organic solvents: soluble (alcohol, acetone and ether)

SMILES string

[H][C@@]1([C@@]([H])(O[N+]([O-])=O)CO2)[C@@]2([H])[C@]([H])(O[N+]([O-])=O)CO1

InChI

1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2

InChI key

MOYKHGMNXAOIAT-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Nitric oxide (NO) donor and nitrovasodilator. Induces stimulation of corpus mucin biosynthesis in vivo. Used to study the role of nitric oxide in the control of cell growth.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

hcodes

H207,H302

Hazard Classifications

Acute Tox. 4 Oral - Desen. Expl. 3

Storage Class

4.1A - Other explosive hazardous materials

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

C Sciorati et al.
British journal of pharmacology, 122(4), 687-697 (1998-01-10)
1. The role of nitric oxide (NO) in the control of cell growth is controversial since both stimulation and (more often) inhibition have been demonstrated in various cell types. In order to reinvestigate the problem and identify the sites of
S Fujii et al.
The American journal of physiology, 274(5 Pt 1), G857-G862 (1998-06-05)
Recently, in vivo electron paramagnetic resonance (EPR) spectroscopy and imaging have been widely used to investigate free radical distribution and metabolism in tissues, organs, and whole body of small animals. Endogenous nitric oxide (NO) is an attractive target of this
Yongliang Jia et al.
International journal of cardiology, 157(3), 330-340 (2011-01-22)
Danshen dripping pill (DSP) is a popular Chinese medicinal product and often compared with isosorbide dinitrate (ISDN) in treating coronary heart disease angina pectoris. Over 100 randomized controlled trials (RCT) have been published in Chinese language but have not been
J A Franciosa
American heart journal, 110(1 Pt 2), 245-250 (1985-07-01)
Nitrates are widely used for the management of congestive heart failure (CHF), as well as angina pectoris. In both situations, nitrates significantly increase exercise capacity. The mechanism of this beneficial effect is unclear, especially in CHF. Isosorbide dinitrate reduces pulmonary
Benjamin Medalion et al.
The Journal of thoracic and cardiovascular surgery, 150(3), 607-612 (2015-07-21)
Bilateral internal thoracic artery grafting in elderly patients is controversial. We compared the outcome of bilateral internal thoracic artery grafting with that of single internal thoracic artery and saphenous vein and radial artery conduits in these patients. Patients aged 70 years
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service