H8258
4-Hydroxy-TEMPO
Synonym(s):
4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl, TEMPOL
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About This Item
Empirical Formula (Hill Notation):
C9H18NO2
CAS Number:
Molecular Weight:
172.24
Beilstein/REAXYS Number:
1422990
EC Number:
MDL number:
UNSPSC Code:
12352200
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69-71 °C (lit.)
storage temp.
2-8°C
SMILES string
CC1(C)CC(O)CC(C)(C)N1[O]
InChI
1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChI key
UZFMOKQJFYMBGY-UHFFFAOYSA-N
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Application
Spin label reagent used in the chatacterization of antagonist and agonist binding sites of NK1 receptor. Also used to measure reactive oxygen generation in heart muscle by electron spin resonance spectroscopy. Cells that overexpress CYP2E1 can be protected from arachidonic acid toxicity damage by TEMPOL.
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Niroz Abu-Saleh et al.
American journal of physiology. Renal physiology, 306(1), F24-F33 (2013-11-08)
Ischemic acute kidney injury (iAKI) in diabetes mellitus is associated with a rapid deterioration of kidney function, more than in nondiabetic subjects. TVP1022, a non-MAO inhibitor S-isomer of rasagiline, possesses antioxidative and antiapoptotic activities. The current study examines the effects
Aziz Guellich et al.
American journal of physiology. Heart and circulatory physiology, 304(11), H1505-H1512 (2013-04-02)
Peroxisome proliferator-activated receptor (PPAR)-α deletion induces a profound decrease in MnSOD activity, leading to oxidative stress and left ventricular (LV) dysfunction. We tested the hypothesis that treatment of PPAR-α knockout (KO) mice with the SOD mimetic tempol prevents the heart
Stefano Lattanzio et al.
Journal of the American Heart Association, 3(4) (2014-07-20)
Dickkopf-1 (DKK-1) is a major regulator of the Wnt signaling pathway, involved in inflammation, atherogenesis, and the regulation of glucose metabolism. Because platelets are major contributors to circulating levels of DKK-1 in other clinical settings, we aimed at characterizing the
Petr Neugebauer et al.
Physical chemistry chemical physics : PCCP, 15(16), 6049-6056 (2013-03-16)
We have performed liquid state ("Overhauser") Dynamic Nuclear Polarization (DNP) experiments at high magnetic field (9.2 T, corresponding to 260 GHz EPR and 400 MHz (1)H-NMR resonance frequency) on aqueous solutions of (14)N-TEMPOL nitroxide radicals. Integrated signal enhancements exceeding -80
Jiang Zhu et al.
American journal of physiology. Heart and circulatory physiology, 304(5), H649-H659 (2013-01-01)
Cardioprotective effects of anesthetic preconditioning and cyclosporine A (CsA) are lost with aging. To extend our previous work and address a possible mechanism underlying age-related differences, we investigated the role of oxidative stress in the aging heart by treating senescent
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