Science (New York, N.Y.), 223(4631), 17-21 (1984-01-06)
Toxins with unusual characteristics are involved in some destructive diseases of plants. Certain parasitic fungi produce toxins of low molecular weight that selectively affect the host plant; nonhosts are tolerant. These toxins have diverse structures, including cyclic peptides and linear
The fungal maize pathogen Cochliobolus carbonum produces a phytotoxic and cytostatic cyclic peptide, HC-toxin, of structure cyclo(D-prolyl-L-alanyl-D-alanyl-L-Aeo), in which Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid. Here we report the isolation of a gene, TOXC, that is present only in HC-toxin-producing (Tox2+)
HC toxin, the host-selective toxin of the maize pathogen Cochliobolus carbonum, inhibited maize histone deacetylase (HD) at 2 microM. Chlamydocin, a related cyclic tetrapeptide, also inhibited HD activity. The toxins did not affect histone acetyltransferases. After partial purification of histone
The fungal pathogen Cochliobolus carbonum race 1 produces a host-selective toxin (HC-toxin) that is responsible for increased virulence on susceptible genotypes of maize. The toxin is synthesized by a peptide synthetase, which is a product of the HTS1 gene. Because
Vaccination with recombinant His-tagged isoforms of the Clostridium botulinum Hc domain of neurotoxin serotype A (rAHc) have effectively protected against challenge with active botulinum neurotoxin serotype A. To establish a formulation suitable for human use, rAHc was expressed in Escherichia
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