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H3635

Sigma-Aldrich

γ-Hydroxybutyric acid sodium salt

Synonym(s):

4-Hydroxybutyric acid sodium salt, γ-Hydroxybutyric acid sodium salt, GHB, Sodium 4-hydroxybutyrate

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About This Item

Linear Formula:
HO(CH2)3COONa
CAS Number:
502-85-2
Molecular Weight:
126.09
Beilstein/REAXYS Number:
3709170
EC Number:
207-953-3
MDL number:
MFCD00004402
UNSPSC Code:
12352200
PubChem Substance ID:
24895583
NACRES:
NA.77

drug control

USDEA Schedule I; Home Office Schedule 4.1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES string

[Na+].OCCCC([O-])=O

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Biochem/physiol Actions

Endogenous GABA analog that induces absence-like seizures. It blocks dopamine release by blocking impulse flow in dopaminergic neurons.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
127K5013
127F5093
127F5075
106H5018
089H3413

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Wan-Ding Ong et al.
Journal of food science, 80(1), E93-E100 (2014-12-23)
Oil-in-water (O/W) emulsion-gel systems containing high oil payloads are of increasing interest for food applications because of the reduction in encapsulation cost, consumption frequency or volume of food products. This study shows a facile approach to prepare stable alginate-based O/W
M Hernandez et al.
The American journal of drug and alcohol abuse, 24(1), 179-183 (1998-03-26)
We describe what we believe is the first psychiatric hospitalization due to GHB-induced delirium reported in the medical literature. We examine the use of the substance gamma hydroxybutyric acid (GHB) and describe the clinical findings in a patient who presented
G Tunnicliff
General pharmacology, 23(6), 1027-1034 (1992-11-01)
1. Administration of the endogenous compound gamma-hydroxybutyric acid (GHB) can induce a sleep-like state in experimental animals and, indeed, it has been used as a general anaesthetic in clinical medicine. 2. Although GHB appears to be a CNS depressant, there
Robert Neijzen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(5), 801-803 (2012-09-29)
Intoxications with gamma-hydroxybutyrate (GHB) are occurring more frequently. Patients are primarily treated symptomatically. The use of activated charcoal (AC) has been suggested in several guidelines and in literature, although the clinical value of AC in GHB intoxication is a matter
Samuel A Roiko et al.
Pharmaceutical research, 30(5), 1338-1348 (2013-01-16)
L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by monocarboxylate transporters. Our objective was to assess the dose-dependence of L-lactate treatment, with and without D-mannitol, on GHB toxicokinetics/toxicodynamics (TK/TD). Rats were administered GHB 600 mg/kg
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