G7379
Guanidinosuccinic acid
Synonym(s):
N-Amidino-L-aspartic acid
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About This Item
Linear Formula:
C5H9O4N3
CAS Number:
Molecular Weight:
175.14
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
powder
color
white
Storage temp.
2-8°C
SMILES string
NC(=N)NC(CC(O)=O)C(O)=O
InChI
1S/C5H9N3O4/c6-5(7)8-2(4(11)12)1-3(9)10/h2H,1H2,(H,9,10)(H,11,12)(H4,6,7,8)
Inchi Key
VVHOUVWJCQOYGG-UHFFFAOYSA-N
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Kazumasa Aoyagi
Molecular and cellular biochemistry, 244(1-2), 11-15 (2003-04-19)
We have reported that (1) the synthesis of GSA, a uremic toxin, increases depending on the urea concentration and (2) GSA is formed from argininosuccinic acid (ASA) and the hydroxyl radical or SIN-1 which generates superoxide and NO simultaneously. However
R D'Hooge et al.
Neuroscience letters, 265(2), 83-86 (1999-05-18)
Guanidine, creatinine (CTN), methylguanidine (MG) and guanidinosuccinic acid (GSA) are four endogenous guanidino compounds with proven neuroexcitatory actions, and putative pathophysiological significance as uraemic toxins. The effects of these uraemic guanidino compounds, were studied on whole-cell current evoked by gamma-amino
Sunny Eloot et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(7), 2225-2232 (2009-02-20)
Patients with renal failure retain a large variety of uraemic solutes, characterized by different kinetic behaviour. It is not entirely clear what the impact is of increasing dialysis frequency and/or duration on removal efficiency, nor whether this impact is the
A Torremans et al.
Kidney international, 69(11), 2003-2012 (2006-04-28)
Polycystic kidney disease (PKD) accounts for 7-10% of all dialyzed renal insufficient patients. Accumulation of specific guanidino compounds (GCs) has been related to neurological, cardiovascular, hematological, and immunological complications of renal failure. In this study, we investigate whether the PKD/Mhm
Kazuharu Ienaga et al.
Biological & pharmaceutical bulletin, 32(7), 1204-1208 (2009-07-03)
The concentration of NZ-419 (5-hydroxy-1-methylimidazolidine-2,4-dione), an intrinsic antioxidant, has been shown to increase in the sera of animals and patients with chronic renal failure (CRF). This is the first report that orally administered exogenous NZ-419 prevents the initiation and/or progression
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