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Key Documents

G5646

Sigma-Aldrich

Gly-Arg-Gly-Asp-Thr-Pro

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C23H39N9O10
CAS Number:
Molecular Weight:
601.61
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

biological source

synthetic (organic)

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(O)C(NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC(=O)CN)C(=O)N1CCCC1C(O)=O

InChI

1S/C23H39N9O10/c1-11(33)18(21(40)32-7-3-5-14(32)22(41)42)31-20(39)13(8-17(36)37)30-16(35)10-28-19(38)12(29-15(34)9-24)4-2-6-27-23(25)26/h11-14,18,33H,2-10,24H2,1H3,(H,28,38)(H,29,34)(H,30,35)(H,31,39)(H,36,37)(H,41,42)(H4,25,26,27)

InChI key

UMZVBZDHGKJFGQ-UHFFFAOYSA-N

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Amino Acid Sequence

Gly-Arg-Gly-Asp-Thr-Pro

Biochem/physiol Actions

Inhibits cell attachment of fibronectin, vitronectin, and Type I collagen.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Zaozao Chen et al.
PloS one, 8(1), e52233-e52233 (2013-01-10)
The issue of how contractility and adhesion are related to cell shape and migration pattern remains largely unresolved. In this paper we report that Gleevec (Imatinib), an Abl family kinase inhibitor, produces a profound change in the shape and migration
S Dedhar et al.
The Journal of cell biology, 104(3), 585-593 (1987-03-01)
To isolate collagen-binding cell surface proteins, detergent extracts of surface-iodinated MG-63 human osteosarcoma cells were chromatographed on affinity matrices of either type I collagen-Sepharose or Sepharose carrying a collagen-like triple-helical peptide. The peptide was designed to be triple helical and
K R Gehlsen et al.
The Journal of cell biology, 106(3), 925-930 (1988-03-01)
The interaction of cells with extracellular matrix components such as fibronectin, vitronectin, and type I collagen has been shown to be mediated through a family of cell-surface receptors that specifically recognize an arginine-glycine-aspartic acid (RGD) amino acid sequence within each

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