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Key Documents

G3894

Sigma-Aldrich

γ-D-Glutamylaminomethylsulfonic acid

Synonym(s):

GAMS

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About This Item

Empirical Formula (Hill Notation):
C6H12N2O6S
CAS Number:
Molecular Weight:
240.23
UNSPSC Code:
12352200
PubChem Substance ID:

form

solid

color

white

mp

216-218 °C

Storage temp.

−20°C

SMILES string

OC([C@H](N)CCC(NCS(O)(=O)=O)=O)=O

InChI

1S/C6H12N2O6S/c7-4(6(10)11)1-2-5(9)8-3-15(12,13)14/h4H,1-3,7H2,(H,8,9)(H,10,11)(H,12,13,14)/t4-/m1/s1

Inchi Key

HCMBCMVOCRJSME-SCSAIBSYSA-N

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Biochem/physiol Actions

Gamma-D-Glutamylaminomethylsulfonic acid (GAMS) is used as a selective antagonist of AMPA/kainate glutamatergic receptors and as an anticonvulsant.
Selective antagonist at AMPA/kainate glutamatergic receptors; anticonvulsant.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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V S Tatarnikov et al.
Bulletin of experimental biology and medicine, 146(5), 551-554 (2009-06-16)
In narcotized albino rats, thermal nociceptive stimulation elevated systemic blood pressure and increased the frequency of respiratory rhythm generation. Unilateral microinjection of ketamine hydrochloride, a selective blocker for NMDA receptors, into A5 region did not change the baseline parameters of
P K Sher
Pediatric neurology, 7(6), 429-435 (1991-11-01)
The relative efficacy of competitive and noncompetitive excitatory amino acid antagonists in preventing hypoxic neuronal injury recently was examined in vitro. Immature (26 days post-conception) fetal mouse cerebral cortical cell cultures were exposed 10 days after plating to 5% oxygen
Jun Liu et al.
Brain research, 1073-1074, 297-304 (2006-02-08)
We have demonstrated that dorsal root ganglion neurons transduced with a recombinant replication-defective herpes simplex virus vector coding for glutamic acid decarboxylase (QHGAD67) release GABA to produce an analgesic effect in rodent models of pain. In this study, we examined
S E Smith et al.
European journal of pharmacology, 187(1), 131-134 (1990-10-02)
DL-beta-N-methylamino-alanine (DL-BMAA; 1-10 mumol i.c.v.) in mice induced a syndrome of: ataxia, ptosis, scratching, jumping, myoclonic jerks, clonic muscle spasms and tonic seizure, which was unaffected by pretreatment with D(-)-4-(3-phosphonoprop-2-enyl)-piperazine-2-carboxylate (D(-)-CPPene; i.p.), or by co-administration of gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS with DL-BMAA;
Aline Lamien-Meda et al.
Phytochemical analysis : PCA, 20(5), 416-420 (2009-07-18)
Arbutin is a skin-whitening agent that occurs naturally in the bark and leaves of various plants. It is commonly quantified in plant extracts and skin-whitening products by HPLC. To develop an alternative gas chromatographic method for the separation and quantification

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