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E6515

Sigma-Aldrich

Methionine Enkephalin-Arg-Gly-Leu

≥97% (HPLC)

Synonym(s):

MERGL, Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu

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About This Item

Empirical Formula (Hill Notation):
C41H61N11O10S
CAS Number:
Molecular Weight:
900.06
UNSPSC Code:
12352200

assay

≥97% (HPLC)

storage temp.

−20°C

Preparation Note

Originally extracted from bovine adrenal medulla

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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C D Márquez et al.
Journal of chromatography. B, Biomedical sciences and applications, 694(1), 21-30 (1997-06-20)
Quantitative analysis of two opioid peptides, DSLET [(D-Ser2)Leu-enkephalin-Thr6] and Met-enkephalin-Arg-Gly-Leu, was performed using microbore liquid chromatography interfaced to electrospray ionization tandem mass spectrometry. Validation of the methodology was demonstrated for each peptide in plasma. Quantitative analyses were performed through the
M Lakomy et al.
Folia histochemica et cytobiologica, 32(3), 167-175 (1994-01-01)
The distribution of vasoactive intestinal polypeptide, substance P, Met5-enkephalin-Arg6-Gly7-Leu8, neuropeptide Y, calcitonin gene-related peptide and bombesin/gastrin releasing peptide was studied immunohistochemically in nerve fibres supplying the vagina and uterine cervix of sexually immature pigs. Nerves containing neuropeptide Y- and Met5-enkephalin-Arg6-Gly7-Leu8-immunoreactivity
T Mimoda et al.
Anatomia, histologia, embryologia, 27(1), 65-69 (1998-03-20)
The duodenum of various ruminants was examined by immunohistochemical staining for serotonin, substance P and Metenkephalin-Arg6-Gly7-Leu8 (MENK8). Serotonin- and substance P-immunoreactive endocrine cells were detected in samples from cow, calf, sheep, goat, and barbary sheep, MENK8-immunoreactive endocrine cells were detected
P A Steele et al.
Cell and tissue research, 284(2), 331-339 (1996-05-01)
Research has suggested that exogenous opioid substances can have direct effects on cardiac muscle or influence neurotransmitter release via presynaptic modulation of neuronal inputs to the heart. In the present study, multiple-labelling immunohistochemistry was employed to determine the distribution of
R Magoul et al.
Peptides, 15(5), 883-892 (1994-01-01)
The morphological support of interactions between enkephalins and three systems--beta-endorphin (beta-END), tyrosine hydroxylase (TH), or neuropeptide Y (NPY)--well represented in the arcuate nucleus, was examined by using an electron microscopic double immunostaining combining two sensitive chromogens, diaminobenzidine (DAB) and tetramethylbenzidine

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