D9549
[Phe4]-Dermorphin fragment 1-4 amide
≥97% (HPLC)
Synonym(s):
TAPP, Tyr-D-Ala-Phe-Phe-NH2
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About This Item
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc2ccccc2)C(=O)NC(Cc3ccccc3)C(N)=O
Gene Information
human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
Biochem/physiol Actions
Selective μ opiate receptor agonist; lipophilic peptide that appears to cross the blood-brain barrier.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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British journal of pharmacology, 119(2), 239-244 (1996-09-01)
1. The effect of i.v. administration of TAPP, a highly selective and exclusively peripherally-acting mu-opioid receptor agonist, on urine output, urinary sodium, potassium and cyclic GMP, and on plasma immunoreactive atrial natriuretic factor (IR-ANF) levels was studied in conscious normally
Peptides, 19(6), 1091-1098 (1998-08-13)
Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31
Journal of medicinal chemistry, 32(3), 698-703 (1989-03-01)
According to the membrane compartment concept the receptor specificity of ligands is based not only on ligand-receptor complementarity but also on specific ligand-membrane interactions. Elaboration of this concept for opioid peptide-receptor interactions had led to the assumption that mu- and
Clinical orthopaedics and related research, 473(9), 2865-2873 (2015-04-22)
Allograft bone is commonly used to augment bone stock. Unfortunately, allograft is prone to bacterial contamination and current antimicrobial therapies are inadequate. Photoactivated porphyrins combat bacterial growth by production of reactive oxygen species (ROS); however, to our knowledge, they have
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