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D8783

Sigma-Aldrich

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt

10 mM in H2O

Synonym(s):

−N7-dGTP, 7-Deaza-dGTP

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About This Item

Empirical Formula (Hill Notation):
C11H17N4O13P3
CAS Number:
101515-08-6
Molecular Weight:
506.19
MDL number:
MFCD00171614
UNSPSC Code:
41106305
PubChem Substance ID:
24894227
NACRES:
NA.52

biological source

Porcine muscle
rabbit muscle

assay

≥95% (HPLC)

form

liquid

concentration

10 mM in H2O

color

colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1

InChI

1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)

InChI key

DLLXAZJTLIUPAI-UHFFFAOYSA-N

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Application

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt has been used as a lysis agent to evaluate its efficiency on direct cell lysis, RNA stability, and compatibility with downstream reverse transcription quantitative real-time PCR during the analyzes of samples with small numbers of cells.

Biochem/physiol Actions

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-deaza-dGTP) competes with natural substrate dGTP and blocks the telomerase activity. This nucleotide once incorporated into the telomere alters the secondary structure of the telomere making it difficult for telomerase to identify it for further telomere synthesis. This dGTP analog pairs weakly with conventional bases to minimize DNA secondary structures, while being a good substrate for DNA polymerases. 7-deaza-dGTP in combination with dimethyl sulfoxide (DMSO) and betaine enhances the polymerase chain reaction (PCR) amplification of GC-rich DNA sequences.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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