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D7441

Sigma-Aldrich

Daltroban

>98% (HPLC)

Synonym(s):

4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO4S
CAS Number:
79094-20-5
Molecular Weight:
353.82
MDL number:
MFCD00868295
UNSPSC Code:
12352200
PubChem Substance ID:
24724468
NACRES:
NA.77

assay

>98% (HPLC)

form

solid

color

white

mp

132.5-137.4 °C (lit.)

solubility

DMSO: soluble 22 mg/mL

SMILES string

OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1

InChI

1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

InChI key

IULOBWFWYDMECP-UHFFFAOYSA-N

Gene Information

human ... TBXA2R(6915)

General description

Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.

Biochem/physiol Actions

Selective thromboxane A2 receptor antagonist

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Milena Koleva et al.
Gastroenterology, 122(3), 697-708 (2002-03-05)
In normal rat liver, anaphylatoxin C5a induces glucose output from hepatocytes indirectly via prostanoids released from Kupffer cells. Correspondingly, it was found that hepatocytes, in contrast to Kupffer cells, did not express C5a receptors. Lipopolysaccharide (LPS) has been reported to
Sabine Pestel et al.
Laboratory investigation; a journal of technical methods and pathology, 83(12), 1733-1741 (2003-12-24)
Various inflammatory stimuli such as anaphylatoxin C5a, zymosan, and lipopolysaccharides (LPSs) have been reported both to enhance glucose output in the perfused rat liver and to induce prostanoid (ie, prostaglandin and thromboxane) release from Kupffer cells, the resident liver macrophages.
Zhi-Dong Ge et al.
Journal of cardiovascular pharmacology, 41(3), 481-488 (2003-02-27)
The purpose of the current study was to compare the efficacy of two structurally unrelated thromboxane A (TXA ) receptor antagonists, KT2-962 and daltroban (BM 13.505), in a dog model of myocardial ischemia/reperfusion injury. Pentobarbital-anesthetized dogs were subjected to left
A Rizzo et al.
The American journal of physiology, 268(5 Pt 2), H1954-H1958 (1995-05-01)
The effects of platelet-activating factor (PAF) on vascular resistance and capillary permeability were studied in the isolated rat hindquarter. Six groups were studied (n = 30): control; PAF alone (1.4 microM); and PAF (1.4 microM) pretreated with ibuprofen (30 mg/kg)
F Bertolino et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(4), 462-466 (1998-01-24)
We sought to determine whether the intrinsic pulmonary hypertensive activity of the purported thromboxane A2/prostanoid (TP) receptor antagonist, daltroban, was mediated by TP receptors, using the high efficacy TP receptor agonist, U-46619, and the silent TP receptor antagonist, SQ 29,548.
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