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D6068

Sigma-Aldrich

N-[4-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenyl]benzamide hydrochloride

≥98% (HPLC), solid

Synonym(s):

4-(4′-Benzamidoanilino)-6,7-dimethoxyquinazoline hydrochloride, Aurora Kinase Inhibitor II

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About This Item

Empirical Formula (Hill Notation):
C23H20N4O3 · HCl
CAS Number:
179247-42-8
Molecular Weight:
436.89
MDL number:
MFCD09265252
UNSPSC Code:
12352200
PubChem Substance ID:
24724466
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

H2O: <2 mg/mL
DMSO: ~2.4 mg/mL (with warming up to 60°C for 1 minute)

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

Cl.COc1cc2ncnc(Nc3ccc(NC(=O)c4ccccc4)cc3)c2cc1OC

InChI

1S/C23H20N4O3.ClH/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15;/h3-14H,1-2H3,(H,27,28)(H,24,25,26);1H

InChI key

OQCLKJREASBKNO-UHFFFAOYSA-N

Biochem/physiol Actions

Aurora Kinase Inhibitor

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Nicola M Heron et al.
Bioorganic & medicinal chemistry letters, 16(5), 1320-1323 (2005-12-13)
A novel series of 5-aminopyrimidinyl quinazolines has been developed from anilino-quinazoline 1, which was identified in a high throughput screen for Aurora A. Introduction of the pyrimidine ring and optimisation of the substituents both on this ring and at the

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