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COO/COA

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D0929

3,3′-Diheptyloxacarbocyanine iodide

Name: 3,3′-Diheptyloxacarbocyanine iodide
Brand: SIGMA

Synonym(s):

DiOC₇(3)

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₄₁IN₂O₂

CAS Number:

53213-83-5

Molecular Weight:

600.57

MDL number:

MFCD00274413

UNSPSC Code:

12171500

PubChem Substance ID:

24893311

fluorescence

λ_ex 484 nm; λ_em 504 nm in methanol

SMILES string

[I-].CCCCCCCN1C(\Oc2ccccc12)=C\C=C\c3oc4ccccc4[n+]3CCCCCCC

InChI

1S/C31H41N2O2.HI/c1-3-5-7-9-15-24-32-26-18-11-13-20-28(26)34-30(32)22-17-23-31-33(25-16-10-8-6-4-2)27-19-12-14-21-29(27)35-31;/h11-14,17-23H,3-10,15-16,24-25H2,1-2H3;1H/q+1;/p-1

InChI key

ANJZLSIIEGUCQL-UHFFFAOYSA-M

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H319,H335,H360

pcodes

P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.

Jennifer H E Baker et al.

PloS one, 8(10), e76832-e76832 (2013-11-10)

Many cancer research efforts focus on exploiting genetic-level features that may be targeted for therapy. Tissue-level features of the tumour microenvironment also represent useful therapeutic targets. Here we investigate the presence of low oxygen tension and sensitivity to NOS inhibition

Pontentiometric cyanine dyes are sensitive probes for mitochondria in intact plant cells : kinetin enhances mitochondrial fluorescence.

Z Liu et al.

Plant physiology, 84(4), 1385-1390 (1987-08-01)

Selected fluorescent dyes were tested for uptake by mitochrondria in intact cells of barley, maize, and onion. The cationic cyanine dye 3,3'-diheptyloxacarbocyanine iodide [DiOC(7)(3)] accumulated in mitochondria within 15 to 30 minutes without appreciable staining of other protoplasmic constituents. The

Use of a carbocyanine dye as a marker of functional vasculature in murine tumours.

M J Trotter et al.

British journal of cancer, 59(5), 706-709 (1989-05-01)

An intravenously administered fluorescent carbocyanine dye, DiOC7(3), has been evaluated for use in conjunction with Hoechst 33342 as a marker of murine tumour vasculature. DiOC7(3) stains cells immediately adjacent to blood vessels and thus, like Hoechst 33342, outlines perfused tumour

Tissue penetration and activity of camptothecins in solid tumor xenografts.

Alastair H Kyle et al.

Molecular cancer therapeutics, 13(11), 2727-2737 (2014-08-22)

The ability of a panel of camptothecin derivatives to access the tumor compartment was evaluated to determine the mechanisms by which the architecture of solid tumors may act to limit their activity. Microregional localization and activity of members of the

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