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C7124

Sigma-Aldrich

Cryptolepine hydrate

≥98% (HPLC)

Synonym(s):

5-Methyl-5H-quindoline hydrate

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About This Item

Empirical Formula (Hill Notation):
C16H12N2 · xH2O
CAS Number:
480-26-2
Molecular Weight:
232.28 (anhydrous basis)
MDL number:
MFCD17215953
UNSPSC Code:
12352200
PubChem Substance ID:
329775140
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

purple

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O.Cn1c2ccccc2cc3nc4ccccc4c13

InChI

1S/C16H12N2.H2O/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;/h2-10H,1H3;1H2

InChI key

AOTFRBDOIUZYCT-UHFFFAOYSA-N

Biochem/physiol Actions

Cryptolepine hydrate is a cytoxic, anti-cancer, antimalarial agent

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
060M4633V
0000036469
0000036470
0000064302
060M4633

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Yumin Zhang et al.
Frontiers in cellular and infection microbiology, 11, 624745-624745 (2021-03-26)
Human babesiosis is a CDC reportable disease in the United States and is recognized as an emerging health risk in multiple parts of the world. The current treatment for human babesiosis is suboptimal due to treatment failures and unwanted side
João Lavrado et al.
Bioorganic & medicinal chemistry letters, 22(19), 6256-6260 (2012-08-29)
Cryptolepine derivatives containing alkyldiamine side-chains, 2, with potent inhibitory activity against Trypanosoma brucei brucei are reported. Compounds 2 showed improved activity and selectivity to T. b. brucei when compared to the lead compound. The most selective compound, 2k, presents a
Noble Kuntworbe et al.
AAPS PharmSciTech, 13(2), 568-581 (2012-04-06)
Cryptolepine hydrochloride-loaded gelatine nanoparticles were developed and characterised as a means of exploring formulation techniques to improve the pharmaceutic profile of the compound. Cryptolepine hydrochloride-loaded gelatine-type (A) nanoparticles were developed base on the double desolvation approach. After optimisation of formulation
Louise R Whittell et al.
Bioorganic & medicinal chemistry, 19(24), 7519-7525 (2011-11-08)
A series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells). Di-halogenated compounds were the most potent derivatives
Yu-Jing Lu et al.
Chemical communications (Cambridge, England), 47(17), 4971-4973 (2011-03-25)
A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective
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