C4188

ω-Conotoxin MVIIC

≥95% (HPLC)

• Empirical Formula (Hill Notation): C₁₀₆H₁₇₈N₄₀O₃₂S₇
• CAS Number: 147794-23-8
• Molecular Weight: 2749.25
• MDL number: MFCD00214640
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775056
• NACRES: NA.32

Properties

• Quality Level: 200
• assay: ≥95% (HPLC)
• form: powder
• composition: Peptide content, ~65%
• storage temp.: −20°C
• SMILES string: CSCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N4CCC[C@H]4C(=O)N2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC3=O)C(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc5ccc(O)cc5)NC1=O)[C@@H](C)O
• InChI: 1S/C106H178N40O32S7/c1-53-103(178)146-36-15-23-75(146)101(176)144-74-52-185-183-49-71-89(164)126-43-79(154)130-62(21-13-34-120-105(115)116)90(165)133-60(20-12-33-119-104(113)114)87(162)124-42-78(153)129-61(18-6-10-31-109)91(166)140-70(83(112)158)48-181-184-51-73(100(175)143-72(99(174)139-68(45-147)88(163)125-44-80(155)131-69(46-148)97(172)141-71)50-182-180-47-57(111)84(159)132-59(17-5-9-30-108)86(161)123-41-77(152)128-58(16-4-8-29-107)85(160)122-40-76(151)127-53)142-96(171)67(39-81(156)157)138-95(170)66(38-55-24-26-56(150)27-25-55)137-93(168)65(28-37-179-3)136-102(177)82(54(2)149)145-94(169)63(19-7-11-32-110)134-92(167)64(135-98(74)173)22-14-35-121-106(117)118/h24-27,53-54,57-75,82,147-150H,4-23,28-52,107-111H2,1-3H3,(H2,112,158)(H,122,160)(H,123,161)(H,124,162)(H,125,163)(H,126,164)(H,127,151)(H,128,152)(H,129,153)(H,130,154)(H,131,155)(H,132,159)(H,133,165)(H,134,167)(H,135,173)(H,136,177)(H,137,168)(H,138,170)(H,139,174)(H,140,166)(H,141,172)(H,142,171)(H,143,175)(H,144,176)(H,145,169)(H,156,157)(H4,113,114,119)(H4,115,116,120)(H4,117,118,121)/t53-,54+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68?,69?,70-,71-,72-,73-,74-,75-,82-/m0/s1
• InChI key: FHVUTHWUIUXZBY-BRYRKPJSSA-N

Description

Amino Acid Sequence

Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2

Biochem/physiol Actions

Inhibits Ca²⁺ channels resistant to ω-Conotoxin GVIA; blocks hippocampal excitatory post-synaptic potential (EPSPs) suggesting an interaction with Q-type voltage-sensitive Ca²⁺ channels (VSCC); originally isolated from marine snail Conus geographus.

Other Notes

Lyophilized from 0.1% TFA in H2O

Legal Information

Sold under license from Cognetix for research purposes only; subject to US patent no. 5,591,821

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)