C153
Cyprodime hydrobromide
>96%, solid
Synonym(s):
(–)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C22H29NO3 · HBr
CAS Number:
Molecular Weight:
436.38
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Recommended Products
assay
>96%
form
solid
optical activity
[α]20/D −82.9°, c = 1.03 in 95% ethanol(lit.)
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 12 mg/mL
H2O: insoluble
ethanol: soluble
SMILES string
Br.COc1cccc2C[C@H]3N(CC[C@@]4(CC(=O)CC[C@@]34OC)c12)CC5CC5
Biochem/physiol Actions
Selective μ opioid receptor antagonist.
Caution
Photosensitive
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ana Baamonde et al.
Naunyn-Schmiedeberg's archives of pharmacology, 372(3), 213-219 (2005-11-12)
The stimulation of peripheral opioid receptors yields analgesic responses in a model of bone cancer-induced pain in mice. In order to know the type(s) of peripheral opiate receptors involved, the paw thermal withdrawal latencies were measured in C3H/HeJ mice bearing
H C Jackson et al.
Psychopharmacology, 111(4), 486-490 (1993-01-01)
This study investigates the possible involvement of opioid receptors in the action of a variety of anticonvulsant agents. The opioid antagonist naloxone (0.3, 1 mg/kg IP) and the selective mu-opioid antagonist cyprodime (3 mg/kg IP) significantly inhibited the increase in
Mariana Spetea et al.
Journal of medicinal chemistry, 47(12), 3242-3247 (2004-05-28)
The synthesis, biological, and pharmacological evaluation of novel derivatives of cyprodime are described. Their binding affinities at mu, delta, and kappa opioid receptors were evaluated using receptor binding assay. It was observed that the affinity of these compounds was sensitive
A Márki et al.
European journal of pharmacology, 383(2), 209-214 (1999-12-11)
The use of compounds with high selectivity for each opioid receptor (mu, delta and kappa) is crucial for understanding the mechanisms of opioid actions. Until recently non-peptide mu-opioid receptor selective antagonists were not available. However, N-cyclopropylmethyl-4,14-dimethoxy-morphinan-6-one (cyprodime) has shown a
S Józefowski et al.
Polish journal of pharmacology, 49(4), 229-237 (1997-08-01)
The head kidney is the main lymphopoietic organ of teleost fish. It is the source of leukocytes inhabiting the peritoneal cavity during an experimental peritoneal inflammation (Gruca et al., Folia Biol.-Kraków, 1997, 44, 137-142). The number of elicited peritoneal leukocytes
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