B157

BQ-788

≥95%, solid

• Synonym(s): 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-N_in-(Methoxycarbonyl)-D-Trp-D-Nle, N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt
• Empirical Formula (Hill Notation): C₃₄H₅₀N₅NaO₇
• CAS Number: 156161-89-6
• Molecular Weight: 663.78
• MDL number: MFCD00797882
• UNSPSC Code: 12352200
• PubChem Substance ID: 329773192
• NACRES: NA.32

Properties

• Quality Level: 200
• assay: ≥95%
• form: solid
• color: white
• solubility: acetonitrile: 0.3 mg/mL; DMSO: 1.2 mg/mL; ethanol: 1.2 mg/mL; H₂O: slightly soluble
• storage temp.: −20°C
• SMILES string: [Na+].CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N3[C@@H](C)CCC[C@H]3C)C([O-])=O
• InChI: 1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1
• InChI key: QCVIFBRTTLMEOV-FUKQNADPSA-M
• Gene Information: human ... EDNRB(1910) ; mouse ... EDNRB(13618) ; rat ... EDNRB(50672)

Description

Application

BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs), uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs)

Biochem/physiol Actions

Selective ET_B endothelin receptor antagonist.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)