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B1186

Sigma-Aldrich

Binucleine 2

≥97% (HPLC)

Synonym(s):

N′-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide

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About This Item

Empirical Formula (Hill Notation):
C13H11N5ClF
CAS Number:
220088-42-6
Molecular Weight:
291.71
MDL number:
MFCD00177827
UNSPSC Code:
12352200
PubChem Substance ID:
24724411
NACRES:
NA.77

assay

≥97% (HPLC)

form

solid

solubility

DMSO: soluble >5 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

CN(C)\C=N\c1c(cnn1-c2ccc(F)c(Cl)c2)C#N

InChI

1S/C13H11ClFN5/c1-19(2)8-17-13-9(6-16)7-18-20(13)10-3-4-12(15)11(14)5-10/h3-5,7-8H,1-2H3/b17-8+

InChI key

MNCYLHJHZOUDLB-CAOOACKPSA-N

Biochem/physiol Actions

Binucleine 2 is a cytokinesis inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Chantal Roubinet et al.
Current biology : CB, 31(18), 3973-3983 (2021-07-24)
Although nuclei are the defining features of eukaryotes, we still do not fully understand how the nuclear compartment is duplicated and partitioned during division. This is especially the case for organisms that do not completely disassemble their nuclear envelope upon

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