B1061
BN82002 hydrochloride
≥97% (HPLC), solid
Synonym(s):
4-Dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]amino)methyl)phenol
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About This Item
Empirical Formula (Hill Notation):
C19H25N3O4 · xHCl
CAS Number:
Molecular Weight:
359.42 (free base basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
≥97% (HPLC)
form
solid
color
tan
solubility
DMSO: 10 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C
Biochem/physiol Actions
BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC50 in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC50 in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).
Caution
Hygroscopic.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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