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B012

Sigma-Aldrich

6-Fluoronorepinephrine hydrochloride

solid

Synonym(s):

6-FNE

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About This Item

Empirical Formula (Hill Notation):
C8H10FNO3 · HCl
CAS Number:
70952-50-0
Molecular Weight:
223.63
MDL number:
MFCD01529921
UNSPSC Code:
12352200
PubChem Substance ID:
24277756

form

solid

color

off-white

solubility

H2O: soluble

SMILES string

FC1=CC(O)=C(O)C=C1C(O)CN.[H]Cl

InChI

1S/C8H10FNO3.ClH/c9-5-2-7(12)6(11)1-4(5)8(13)3-10;/h1-2,8,11-13H,3,10H2;1H

InChI key

QGDCLYPALFHCCD-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
rat ... Adra1a(29412) , Adra2a(25083) , Adrb1(24925) , Adrb2(24176)

Biochem/physiol Actions

α-adrenoceptor agonist.

Caution

Photosensitive. Solutions slowly oxidize in light/oxygen in a manner comparable to norepinephrine hydrochloride.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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R C Ferry et al.
The Journal of biological chemistry, 269(50), 31850-31857 (1994-12-16)
Exposure of P11 cells to serotonin (5-HT) resulted in a transient increase in levels of 5-HT2A receptor mRNA. Exposure to 5-HT for as short a time as 1 min was sufficient to trigger a delayed increase in receptor mRNA. 5-HT-induced
A Pilc et al.
Brain research, 493(1), 8-13 (1989-07-24)
Intraperitoneal administration of 0.8 mg/kg N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) to rats significantly reduced alpha-adrenoceptor binding in cerebral cortical membranes without affecting beta-adrenoceptor sites. A selective reduction in alpha 1-adrenoceptors was achieved by injecting yohimbine prior to EEDQ, whereas prazosin pretreatment yielded a
D Cantacuzene et al.
Science (New York, N.Y.), 204(4398), 1217-1219 (1979-06-15)
Substitution of fluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the alpha- and beta-adrenergic agonist properties of norephinephrine. The 6-fluoro isomer is an beta-adrenergic agonist with virtually no beta agonist activity
Eric A Stone et al.
The international journal of neuropsychopharmacology, 14(3), 319-331 (2010-05-13)
The present study examined the ability of 6-fluoronorepinephrine (6FNE), a full selective α-adrenoceptor agonist, to produce antidepressant-like effects in mice. The drug, administered in the 4th ventricle, produced marked anti-immobility effects at mid-dose range in the acute forced swim, tail
Robert Papay et al.
The Journal of comparative neurology, 497(2), 209-222 (2006-05-18)
alpha(1)-Adrenergic receptors (ARs) are not well defined in the central nervous system. The particular cell types and areas that express these receptors are uncertain because of the lack of high avidity antibodies and selective ligands. We have developed transgenic mice
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