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A9834

Sigma-Aldrich

2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine

≥98%

Synonym(s):

AMT

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About This Item

Empirical Formula (Hill Notation):
C5H10N2S · HCl
CAS Number:
1121-91-1
Molecular Weight:
166.67
MDL number:
MFCD00717539
UNSPSC Code:
12352202
PubChem Substance ID:
24278017
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

assay

≥98%

form

powder

solubility

water: 25 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

Cl[H].CC1CCN=C(N)S1

InChI

1S/C5H10N2S.ClH/c1-4-2-3-7-5(6)8-4;/h4H,2-3H2,1H3,(H2,6,7);1H

InChI key

HVJCRMIQAMEJNM-UHFFFAOYSA-N

Gene Information

human ... FPGS(2356)

Biochem/physiol Actions

As a selective type II (inducible) nitric oxide synthase (NOS) inhibitor, AMT was tested against LPS-induced inflammation in rats.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Nakane et al.
Molecular pharmacology, 47(4), 831-834 (1995-04-01)
We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine. Ki values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine were obtained with partially purified preparations of inducible nitric oxide synthase.
W R Tracey et al.
Canadian journal of physiology and pharmacology, 73(5), 665-669 (1995-05-01)
Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit
Axelle Cooreman et al.
International journal of molecular sciences, 23(9) (2022-05-15)
Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels release adenosine triphosphate (ATP), which triggers inflammation. Over the past two years, azithromycin, chloroquine, dexamethasone, favipiravir, hydroxychloroquine, lopinavir, remdesivir
Ju Hee Lee et al.
Archives of pharmacal research, 38(7), 1304-1311 (2015-03-07)
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in

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