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A5296

Sigma-Aldrich

Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe amide

≥97% (HPLC)

Synonym(s):

A-18-F-NH2

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About This Item

Empirical Formula (Hill Notation):
C89H130N24O24
CAS Number:
99588-52-0
Molecular Weight:
1920.13
MDL number:
MFCD00076703
UNSPSC Code:
12352200
PubChem Substance ID:
24890965

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(C)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(Cc2ccccc2)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N5CCCC5C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc6ccccc6)C(N)=O

Biochem/physiol Actions

Attenuates analgesic effects of morphine

Other Notes

Endogenous peptide found in periaqueductal grey and in dorsal spinal cord

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
099H0739
081H07332
099H07391

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H Y Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(22), 7757-7761 (1985-11-01)
Two peptides that crossreact with an antiserum raised against Phe-Met-Arg-Phe-NH2 were purified from bovine brain extract. Their structures were determined to be Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe- NH2 and Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2. The sequences were determined by gas-phase sequencing, except for the COOH-terminal phenylalaninamides. These were

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