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About This Item
Empirical Formula (Hill Notation):
C9H11N5O4
CAS Number:
Molecular Weight:
253.21
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
≥98% (TLC)
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H](C[C@H]1N=[N+]=[N-])N2C=CC(=O)NC2=O
Application
3′-Azido-2′,3′-dideoxyuridine has shown potent anti-HIV activity in vitro.
Biochem/physiol Actions
Inhibitor of HIV replication.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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C K Chu et al.
Journal of medicinal chemistry, 33(8), 2188-2192 (1990-08-01)
A significant number of patients with AIDS and AIDS-related complex develop neurological complications. Therefore, it is critical that anti-HIV agents penetrate the blood-brain barrier and suppress viral replication in the brain. In an effort to increase the brain delivery of
Linghui Kong et al.
Antiviral chemistry & chemotherapy, 14(5), 263-270 (2003-12-26)
3'-Azido-2', 3'-dideoxyuridine (AZDU, AzddU, CS-87) has been shown to have potent anti-HIV activity in vitro. However, the compound exhibits a relatively short half-life and incomplete oral bioavailability in humans. In an effort to improve the pharmacokinetic properties of AZDU, prodrug
B F Eriksson et al.
Antimicrobial agents and chemotherapy, 33(10), 1729-1734 (1989-10-01)
3'-Azido-2',3'-dideoxyuridine-5'-triphosphate was found to be a potent and highly selective inhibitor of human immunodeficiency virus type 1 and simian immunodeficiency virus reverse transcriptases. The affinity of 3'-azido-2',3'-dideoxyuridine-5'-triphosphate for the reverse transcriptases was similar to that observed for 3'-azido-3'-deoxythymidine-5'-triphosphate. Both compounds
T N Clark et al.
Journal of chromatography. B, Biomedical sciences and applications, 755(1-2), 165-172 (2001-06-08)
3'-Azido-2',3'-dideoxyuridine (AZDU, Azddu, CS-87) is a nucleoside analog of 3'-azido-3'-deoxythymidine (zidovudine, AZT) that has been shown to inhibit human immunodeficiency virus (HIV-1). AZDU is a potential candidate for treatment of pregnant mothers to prevent prenatal transmission of HIV/AIDS to their
K J Doshi et al.
Drug metabolism and disposition: the biological fate of chemicals, 17(6), 590-594 (1989-11-01)
The pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU, CS-87), active anti-HIV compounds, were characterized in uninfected mice. Sensitive and specific HPLC techniques were used to quantitate AZT and AZddU concentrations in serum and brain homogenates following iv doses of 50
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