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A3180

Sigma-Aldrich

Amyloid β-Protein Fragment 12-28

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C89H135N25O25
CAS Number:
107015-83-8
Molecular Weight:
1955.18
MDL number:
MFCD00133075
UNSPSC Code:
12352200
PubChem Substance ID:
24890728

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc2cnc[nH]2)NC(=O)C(N)C(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc3ccccc3)C(=O)NC(Cc4ccccc4)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(O)=O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(O)=O

Gene Information

human ... APP(351)

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Amino Acid Sequence

Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys

Biochem/physiol Actions

Impairs post-training memory in mice upon injection into limbic system structures.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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E M Castaño et al.
Biochemical and biophysical research communications, 141(2), 782-789 (1986-12-15)
Two synthetic peptides corresponding to the reported 28-residue sequence of Alzheimer's Disease beta-protein (SP28) and to residues 12-28 (SP17) were used to form fibrils in vitro. Synthetic fibrils bound Congo Red and closely resembled amyloid fibrils isolated from leptomeninges and

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