A0401

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

• Synonym(s): ACTH4-10
• Empirical Formula (Hill Notation): C₄₄H₅₉N₁₃O₁₀S
• CAS Number: 4037-01-8
• Molecular Weight: 962.09
• MDL number: MFCD00167482
• UNSPSC Code: 12352202
• PubChem Substance ID: 24890423
• NACRES: NA.26

Properties

• Product Name: Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)
• assay: ≥97% (HPLC)
• form: powder
• color: white
• UniProt accession no.: P01189; P47866
• storage temp.: −20°C
• SMILES string: CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O
• InChI: 1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)
• InChI key: HAAUASBAIUJHAN-UHFFFAOYSA-N
• Gene Information: human ... POMC(5443) ; rat ... Crhr2(64680)

Description

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Quality

Lacks adrenocorticotropic activity.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)