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89282

Sigma-Aldrich

Thymidine 5′-diphosphate sodium salt

≥90% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O11P2 · xNa+
CAS Number:
108322-12-9
Molecular Weight:
402.19 (free acid basis)
EC Number:
306-019-3
MDL number:
MFCD00084748
UNSPSC Code:
41106305
PubChem Substance ID:
57653338

biological source

animal
plant

assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])([O-])=O)O2)C(=O)NC1=O

InChI

1S/C10H16N2O11P2.3Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t6-,7+,8+;;;/m0.../s1

InChI key

HBYPEEZBYHQLDM-SPSULGLQSA-K

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Application

Thymidine ′-diphosphate (dTDP) may be used to study the distribution and kinetics of various nucleoside diphosphate kinases and dTDP specific nucleoside diphosphate kinases.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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S Schaertl et al.
The Journal of biological chemistry, 274(29), 20159-20164 (1999-07-10)
The Ser122 --> Pro mutation in human nucleoside diphosphate kinase (NDK)-B/Nm23-H2 was recently found in melanoma cells. In comparison to the wild-type enzyme, steady state activity of NDKS122P with ATP and TDP as substrates was slowed down 5-fold. We have
Chia-Yi Chien et al.
FEBS letters, 583(13), 2281-2286 (2009-06-23)
The existence of multifunctional enzymes in the nucleotide biosynthesis pathways is believed to be one of the important mechanisms to facilitate the synthesis and the efficient supply of deoxyribonucleotides for DNA replication. Here, we used the bacterially expressed yeast thymidylate
P Gonin et al.
Biochemistry, 38(22), 7265-7272 (1999-06-03)
Nucleoside diphosphate (NDP) kinases display low specificity with respect to the base moiety of the nucleotides and to the 2'-position of the ribose, but the 3'-hydroxyl is found to be important for catalysis. We report in this paper the enzymatic
A Yano et al.
Plant molecular biology, 27(5), 1053-1058 (1995-03-01)
The GST (glutathione S-transferase)-NDK (nucleoside diphosphate kinase) fusion protein was expressed in Escherichia coli. The GST-NDK protein was capable of transferring gamma-phosphate from ATP to nucleoside diphosphates such as GDP, CDP, TDP and UDP. Western blot analysis using anti-NDK antibody

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