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74480

Sigma-Aldrich

L-Norepinephrine hydrochloride

≥98.0% (sum of enantiomers, HPLC)

Synonym(s):

L-Arterenol hydrochloride, L-Noradrenaline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
329-56-6
Molecular Weight:
205.64
Beilstein/REAXYS Number:
3916100
EC Number:
206-345-5
MDL number:
MFCD00064560
UNSPSC Code:
12352209
PubChem Substance ID:
57652452
NACRES:
NA.77

assay

≥98.0% (sum of enantiomers, HPLC)

form

crystals

optical activity

[α]20/D −38.5±5°, c = 2% in H2O

mp

~150 °C (dec.)

storage temp.

2-8°C

SMILES string

Cl[H].NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1

InChI key

FQTFHMSZCSUVEU-QRPNPIFTSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Biochem/physiol Actions

Adrenal medullary stress hormone, mediator of the fight-or-flight response; and the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) nervous system.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hypertension (Dallas, Tex. : 1979), 64(1), 178-184 (2014-05-07)
Excessive renal efferent sympathetic nerve activity contributes to hypertension in many circumstances. Although both hemodynamic and tubular effects likely participate, most evidence supports a major role for α-adrenergic receptors in mediating the direct epithelial stimulation of sodium retention. Recently, it
Wataru Inoue et al.
Nature neuroscience, 16(5), 605-612 (2013-04-09)
Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypothalamus
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