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51010

Sigma-Aldrich

4-Methylumbelliferyl 4-guanidinobenzoate hydrochloride hydrate

≥85% (HPLC)

Synonym(s):

4-Guanidinobenzoic acid 4-methylumbelliferyl ester hydrochloride, MUGB

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About This Item

Empirical Formula (Hill Notation):
C18H15N3O4 · HCl · xH2O
CAS Number:
34197-46-1
Molecular Weight:
373.79 (anhydrous basis)
EC Number:
251-871-0
MDL number:
MFCD00043263
UNSPSC Code:
12352204
PubChem Substance ID:
57651297

assay

≥85% (HPLC)

form

powder

fluorescence

λex 323 nm; λem 464 nm (solvent pH 6.0)
λex 360 nm; λem 449 nm (Reaction Product)

storage temp.

2-8°C

SMILES string

Cl[H].CC1=CC(=O)Oc2cc(OC(=O)c3ccc(NC(N)=N)cc3)ccc12

InChI

1S/C18H15N3O4.ClH/c1-10-8-16(22)25-15-9-13(6-7-14(10)15)24-17(23)11-2-4-12(5-3-11)21-18(19)20;/h2-9H,1H3,(H4,19,20,21);1H

InChI key

DAFWZROYEOVJAL-UHFFFAOYSA-N

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Other Notes

Fluorimetric titrant for α- and β-trypsin, thrombin and Factor Xa[1][2]

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBR6641V
BCBC5583V
BCBC5583
1374977

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Some sensitive methods for the assay of trypsinlike enzymes.
P L Coleman et al.
Methods in enzymology, 45, 12-26 (1976-01-01)
G W Jameson et al.
The Biochemical journal, 131(1), 107-117 (1973-01-01)
Several esters of 4-methylumbelliferone and 2-naphthol were synthesized and examined as possible spectrofluorimetric titrants for bovine alpha-chymotrypsin, trypsin, thrombin, Factor Xa and for subtilisin Novo. 4-Methylumbelliferyl p-guanidinobenzoate hydrochloride (MUGB) is a satisfactory titrant for alpha- and beta-trypsin, thrombin and Factor
Lambro A Johnson et al.
Analytical biochemistry, 608, 113907-113907 (2020-08-20)
Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for thrombin. The coupled reactions result in accelerating p-nitroaniline (pNA) production
J Grandoni et al.
Haemophilia : the official journal of the World Federation of Hemophilia, 23(2), 300-308 (2016-12-21)
LR769 is a new second-generation recombinant human Factor VIIa (rhFVIIa) developed for haemophilia treatment. We determined enzymatic properties of LR769 and its interaction with antithrombin, tissue factor, platelets and endothelial protein C receptor (EPCR), compared with NovoSevenRT. Kinetic enzyme assays
Simon J de Veer et al.
The Biochemical journal, 469(2), 243-253 (2015-05-20)
Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesizing a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor's resistance to hydrolysis and

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