30320

Cytidine 5′-triphosphate disodium salt hydrate

≥90.0% (HPLC)

• Synonym(s): 5-CTP-Na₂, CTP
• Empirical Formula (Hill Notation): C₉H₁₄N₃Na₂O₁₄P₃ · xH₂O
• CAS Number: 652154-13-7
• Molecular Weight: 527.12 (anhydrous basis)
• Beilstein/REAXYS Number: 3582735
• MDL number: MFCD00150809
• UNSPSC Code: 41106305
• PubChem Substance ID: 57648425
• NACRES: NA.51

Properties

• assay: ≥90.0% (HPLC)
• form: solid
• impurities: ≤12% water
• solubility: H₂O: 50 mg/mL, clear, colorless
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O
• InChI: 1S/C9H16N3O14P3.2Na.H2O/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
• InChI key: IJMSOWKYYIROGP-LLWADOMFSA-L

Description

Application

Cytidine 5′-triphosphate disodium salt hydrate has been used:

• in the oligonucleotide synthesis for silver nanoclusters interaction studies
• as an anion source for fluorescence emission and titration curve-analysis of hypocrellin A-zinc(II) complex
• in fluorescence emission experiments of copper(II)–2,6-bis(2-benzimidazolyl)pyridine complex

Cytidine 5γ-triphosphate (CTP) is used to synthesize RNA by various RNA polymerases. Cytidine 5γ-triphosphate (CTP) is a substrate for CMP-neuNAc synthetase(s) which produce CMP-neuNAc used in sialylation reactions. As a substrate of CTP:phosphocholine cytidylyltransferase(s) (CT), CTP supports the formation of phosphatidylcholine via the formation of CDP-choline.

Biochem/physiol Actions

Cytidine 5′-triphosphate (CTP) is essential for the synthesis of DNA and is a mediator of many physiological processes in living systems. It is crucial for the dolichol phosphorylation, cholesterol transport and is involved in the allosteric regulation of aspartate transcarbamylase. It is also used in the treatment of disease related brain.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: Eyeshields, Gloves, type N95 (US)