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30153

Sigma-Aldrich

Potassium 2-mercaptoethanesulfonate

≥95% (T)

Synonym(s):

2-Mercaptoethanesulfonic acid potassium salt, Coenzyme M potassium salt, MES potassium salt

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About This Item

Linear Formula:
HSCH2CH2SO3K
CAS Number:
126397-51-1
Molecular Weight:
180.29
MDL number:
MFCD17215943
UNSPSC Code:
12352200
PubChem Substance ID:
329753443

assay

≥95% (T)

storage temp.

−20°C

SMILES string

[K+].[O-]S(=O)(=O)CCS

InChI

1S/C2H6O3S2.K/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1

InChI key

XXZMREMZWJKGRQ-UHFFFAOYSA-M

Application

2-Mercaptoethanesulfonic acid salts (Coenzyme M potassium salt, MESK) are used as an antioxidant and cytoprotective agent in a wide variety of applications from protection from toxicity of therapeutic agents, such as cyclophosphamide and to prevention of brain injury damage.

Biochem/physiol Actions

Metabolite in microbial metabolism in diverse environments and methane metabolism ; methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methano-genesis; can be determined with chemiluminescence detection by flow injection analysis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A A Garcia
The Annals of pharmacotherapy, 29(6), 590-591 (1995-06-01)
To report a case of possible ifosfamide-induced Fanconi syndrome in and adult with cancer. A 20-year old man was treated for an osteosarcoma with a chemotherapy regimen that included ifosfamide, methotrexate, and doxorubicin. Three months after completing therapy he developed
M J Wargovich et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 5(5), 355-360 (1996-05-01)
We assessed the effects of 41 potential chemopreventive agents in the F344 rat using the inhibition of carcinogen-induced aberrant crypt foci (ACF) in the colon as the measure of efficacy. ACF were induced by the carcinogen azoxymethane in F344 rats
L F Capitán-Vallvey et al.
Talanta, 51(6), 1155-1161 (2008-10-31)
A flow injection method with chemiluminescence (CL) detection is proposed for the determination of sodium 2-mercaptoethane sulfonate (MESNA), a drug often used to reduce the urotoxic effects of antineoplastic alkylating agents. The procedure is based on the reaction of the
The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats.
Yilmaz ER, Kertmen H, et al.
Acta Neurochirurgica (2012)

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