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89871

Sigma-Aldrich

Toluene 2,4-diisocyanate

technical, ≥90% (GC)

Synonym(s):

Toluene diisocyanate, 2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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About This Item

Empirical Formula (Hill Notation):
C9H6N2O2
CAS Number:
584-84-9
Molecular Weight:
174.16
Beilstein/REAXYS Number:
744602
EC Number:
209-544-5
MDL number:
MFCD00002011
UNSPSC Code:
12162002

grade

technical

assay

≥90% (GC)

refractive index

n20/D 1.567

bp

124-126 °C/18 mmHg (lit.)
251 °C (lit.)

mp

19.5-21.5 °C (lit.)

density

1.22 g/mL at 20 °C (lit.)

SMILES string

Cc1ccc(cc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

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may become turbid on storage

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Dominika Swierczyńska-Machura et al.
Medycyna pracy, 63(1), 97-103 (2012-07-11)
Diisocyanates are currently the most common cause of occupational asthma in industrialized countries, where its prevalence ranges from less than 5% to 15%. They are mainly used in the production of polyurethane foam, plastic packagings, laminates and polyurethane paints. The
Islam Mohammed Nurul et al.
International immunopharmacology, 11(11), 1766-1772 (2011-07-26)
Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects
Margarete Niebuhr et al.
Experimental dermatology, 21(1), 52-56 (2011-12-14)
The complement system has emerged as a bridge between innate and adaptive immune responses. An involvement of C3aR has been described during skin inflammation. The aim of the study was to investigate the role of C3a in a mouse model
Shrabanti Dev et al.
International immunopharmacology, 11(10), 1504-1509 (2011-05-24)
Previously, we have shown that hot water extract from Kujin, the dried roots of Sophora flavescens alleviates allergic symptoms by suppressing histamine signaling at the transcription level in toluene 2,4-diisocyanate (TDI)-sensitized rats. To know more insights into the mechanism of
Yoo Seob Shin et al.
Current opinion in allergy and clinical immunology, 13(2), 125-131 (2013-01-18)
Diisocyanates are the most common cause of occupational asthma in many industrialized countries, and various pathogenic mechanisms have been suggested to be involved. Occupational asthma causes airway remodeling unless diagnosed and treated within a proper time frame. However, treatment modalities
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