156248

Sodium ethoxide

95%

• Synonym(s): Sodium ethylate
• Linear Formula: CH₃CH₂ONa
• CAS Number: 141-52-6
• Molecular Weight: 68.05
• Beilstein/REAXYS Number: 3593646
• MDL number: MFCD00012417
• UNSPSC Code: 12352100
• PubChem Substance ID: 57647509
• NACRES: NA.21

Properties

• vapor density: 1.6 (vs air)
• Quality Level: 200
• vapor pressure: <0.1 mmHg ( 20 °C)
• assay: 95%
• form: powder
• SMILES string: [Na+].CC[O-]
• InChI: 1S/C2H5O.Na/c1-2-3;/h2H2,1H3;/q-1;+1
• InChI key: QDRKDTQENPPHOJ-UHFFFAOYSA-N

Description

General description

Sodium ethoxide (Sodium ethylate) is a sodium alkoxide. It has been synthesized by reacting sodium with ethanol. It undergoes decomposition in the presence of water to afford ethanol and sodium hydroxide. It is widely employed as a strong base in organic synthesis studies.

Application

• Organic solvent fractionation in lignin depolymerization: A study focused on enhancing the monophenolic yield of lignin depolymerization using a dualistic aprotic solvent system, employing sodium ethoxide for effective organic solvent fractionation. This approach underscores the versatility of sodium ethoxide in complex organic synthesis and biomass processing (Xu et al., 2024).


• Solid-state self-quenching-resistant sulfur dots: Research on sulfur dots utilized a solvent-type passivation strategy to control solid-state self-quenching-resistant behavior, where sodium ethoxide played a crucial role in the synthesis process. This study illustrates sodium ethoxides utility in advanced materials synthesis, particularly for optoelectronic applications (Wu et al., 2022).


• Synthesis of corrosion inhibitors: Sodium ethoxide was used in the efficient synthesis of 6,7-Dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile compounds, demonstrating its applicability as a base in the synthesis of corrosion inhibitors for steel alloys. This application combines computational and practical approaches to highlight sodium ethoxide′s role in materials science and corrosion prevention (Abd El-Lateef et al., 2022).


• Colon-targeted drug delivery systems: The design and synthesis of Thieno[2,3-b]pyridines-chitosan nanocomposites for colon targeting employed sodium ethoxide. This research showcases sodium ethoxides application in the preparation of targeted drug delivery systems, focusing on enhancing the efficacy and specificity of pharmaceutical treatments (Mansour et al., 2020).


• Synthesis of antimicrobial compounds: Sodium ethoxide was integral in the synthesis of novel bis-alpha,beta-unsaturated ketones and nicotinonitrile derivatives, aimed at antimicrobial applications. This study highlights the compound′s critical role in the development of new antimicrobial agents, demonstrating its utility in medicinal chemistry (Altalbawy, 2013).

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H228,H251,H314
• pcodes: P210 - P235 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Flam. Sol. 1 - Self-heat. 1 - Skin Corr. 1A
• supp_hazards: EUH014
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• wgk_germany: WGK 1
• flash_point_f: 86.0 °F - closed cup
• flash_point_c: 30 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges