850365P

18:0 PC (DSPC)

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)
• Empirical Formula (Hill Notation): C₄₄H₈₈NO₈P
• CAS Number: 816-94-4
• Molecular Weight: 790.15
• MDL number: MFCD00036905
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1,2-distearoyl-sn-glycero-3-phosphocholine
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 g (850365P-1G); pkg of 1 × 200 mg (850365P-200MG); pkg of 1 × 25 mg (850365P-25MG); pkg of 1 × 500 mg (850365P-500MG)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• application(s): advanced drug delivery
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
• InChI: 1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
• InChI key: NRJAVPSFFCBXDT-HUESYALOSA-N

Description

General description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons.[1] It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).[2]

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used:

• in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts[2]
• in the preparation of liposomes for immobilization studies[3]
• in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery[4]

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system.[1] It is majorly used in conventional and stealth liposome preparation for drug delivery studies.[2]

Packaging

20 mL Clear Glass Screw Cap Vial (850365P-1G)

20 mL Clear Glass Screw Cap Vial (850365P-500MG)

5 mL Amber Glass Screw Cap Vial (850365P-200MG)

5 mL Amber Glass Screw Cap Vial (850365P-25MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable