699855P

3D-(6-acyl) PHAD^™

Avanti Research^™ - A Croda Brand

• Synonym(s): Monophosphoryl Hexa-acyl Lipid A, 3-Deacyl (Synthetic)
• Empirical Formula (Hill Notation): C₉₆H₁₈₄N₃O₂₁P
• CAS Number: 252042-59-4
• Molecular Weight: 1747.47
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• assay: >99% (HPLC)
• form: powder
• packaging: pkg of 1 × 1 mg (699855P-1mg); pkg of 1 × 10 mg (699855P-10MG); pkg of 1 × 10 mg (699855P-25MG); pkg of 1 × 5 mg (699855P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• application(s): vaccine development
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

Description

General description

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD^™), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.

Application

3D-(6-acyl) PHAD^™ has been used:

• as a synthetic adjuvant in human papillomavirus (HPV) and virus-like particles (VLPs)-based HPV vaccine preparations
• as a component of liposomes for immunizing mice with P. falciparum (Pfs25) malaria transmission-blocking vaccine antigen candidate
• in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice

Packaging

2 mL Amber Glass Crimp Cap Vial (699855P-1mg)

2 mL Amber Glass Crimp Cap Vial (699855P-5mg)

5 mL Amber Glass Screw Cap Vial (699855P-10MG);5 mL Amber Glass Screw Cap Vial (699855P-25MG)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

PHAD is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: No data available
• flash_point_c: No data available