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W425001

Sigma-Aldrich

Piperazine

99%

Synonym(s):

1,4-Diazacyclohexane, Diethylenediamine

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About This Item

Empirical Formula (Hill Notation):
C4H10N2
CAS Number:
110-85-0
Molecular Weight:
86.14
FEMA Number:
4250
Beilstein/REAXYS Number:
102555
EC Number:
203-808-3
MDL number:
MFCD00005953
UNSPSC Code:
12164502
PubChem Substance ID:
329830688
Flavis number:
14.141

biological source

synthetic

vapor pressure

0.8 mmHg ( 20 °C)

assay

99%

expl. lim.

14 %

bp

145-146 °C (lit.)

mp

109-112 °C (lit.)

solubility

H2O: 0.9 g/L at 20 °C

application(s)

flavors and fragrances

organoleptic

camphoraceous

SMILES string

C1CNCCN1

InChI

1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

InChI key

GLUUGHFHXGJENI-UHFFFAOYSA-N

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Danger

Hazard Classifications

Eye Dam. 1 - Flam. Sol. 1 - Repr. 2 - Resp. Sens. 1B - Skin Corr. 1B - Skin Sens. 1B

Storage Class

4.1B - Flammable solid hazardous materials

wgk_germany

WGK 1

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
04097MJ
05519CH
01920AE

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Enza Lacivita et al.
Journal of medicinal chemistry, 55(14), 6375-6380 (2012-06-29)
Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT(7) affinities in the
Slavka Hamulakova et al.
European journal of medicinal chemistry, 55, 23-31 (2012-07-24)
New tacrine derivatives 5a-d, 6a-d with piperazino-ethyl spacer linked with corresponding secondary amines and tacrine homodimer 8 were synthesized and tested as cholinesterase inhibitors on human acetylcholinesterase (hAChE) and human plasmatic butyrylcholinesterase (hBChE). In most cases the majority of synthesized
Mitsunori Kono et al.
Bioorganic & medicinal chemistry, 21(1), 28-41 (2012-12-12)
A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of the lead compound 3
Yuji Nakamura et al.
Bioorganic & medicinal chemistry letters, 22(14), 4561-4566 (2012-06-26)
Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P(3)-P(1) portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4-hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without using the interaction to the S(3)(sp) pocket. Compound 31 exhibited >10,000-fold selectivity over other human proteases, and 18.5% oral bioavailability
R A Lovell
The Veterinary clinics of North America. Small animal practice, 20(2), 453-468 (1990-03-01)
Review of all reports involving anthelmintics in dogs and cats to the IAPIC between January 1, 1986 and August 10, 1988, revealed that ivermectin (extra-label use) and piperazine accounted for over 50% of the calls assessed as toxicoses and suspected
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