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T34908

Sigma-Aldrich

D-Thyroxine

99%

Synonym(s):

3,3′,5,5′-Tetraiodo-D-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-D-alanine

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About This Item

Empirical Formula (Hill Notation):
C15H11I4NO4
CAS Number:
51-49-0
Molecular Weight:
776.87
Beilstein/REAXYS Number:
2954910
MDL number:
MFCD00063056
UNSPSC Code:
12352101
PubChem Substance ID:
329826769
Pricing and availability is not currently available.

assay

99%

mp

~235 °C (dec.)

SMILES string

N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1

InChI key

XUIIKFGFIJCVMT-GFCCVEGCSA-N

Gene Information

human ... THRA(7067) , THRB(7068)

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Certificates of Analysis (COA)

Lot/Batch Number
08367HG
05262TQ
04027PX
09827MF

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F Parker
Journal of the American Academy of Dermatology, 13(1), 1-30 (1985-07-01)
The ability to recognize diverse clinical forms of xanthomas, such as tuberous, planar, eruptive and tendinous, is important in the detection of underlying systemic disease. A variety of primary genetic disorders, as well as numerous secondary conditions such as diabetes
P Hamon et al.
The Journal of clinical endocrinology and metabolism, 67(5), 1089-1093 (1988-11-01)
A 15-month-old boy had clinical features of hyperthyroidism. In spite of elevated serum thyroid hormone levels (mean serum T4, 230 nmol/L; T3, 4.2 nmol/L), serum TSH levels ranged between 3.3-5.6 mU/L and rose to 35.4 mU/L after TRH stimulation. There
R S Perry
Clinical pharmacy, 5(2), 113-127 (1986-02-01)
The biochemistry, etiology, and evaluation of hyperlipidemia and its management, including dietary and drug therapies, are discussed. Strong evidence supports the role of increased cholesterol concentrations as an independent risk factor for coronary artery disease (CAD); however, evidence that elevated
R Narihara et al.
Neurochemistry international, 25(5), 451-454 (1994-11-01)
The effects of thyroxine and its related derivatives on gamma-aminobutyric acid (GABA) receptors in the rat brain were examined. D-Thyroxine strongly inhibited [3H]flunitrazepam binding to benzodiazepine receptor in crude synaptic membrane from the rat brain. The Scatchard analysis of the
F Dorey et al.
Clinical endocrinology, 32(2), 221-228 (1990-02-01)
Selective pituitary resistance to thyroid hormone (PRTH) is responsible for thyrotoxicosis due to inappropriate secretion of TSH. The TSH suppressive action of D-thyroxine (DT4) has been previously documented in euthyroid and hypothyroid subjects. This prompted us to treat with DT4
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