M4546
5-(4-Methoxyphenyl)pyrrolo[2,1-d][1,5]benzothiazepin-4-ol acetate
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About This Item
Empirical Formula (Hill Notation):
C21H17NO3S
CAS Number:
Molecular Weight:
363.43
MDL number:
UNSPSC Code:
12352100
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)C2=C(OC(C)=O)c3cccn3-c4ccccc4S2
Biochem/physiol Actions
Specific ligand for mitochondrial benzodiazepine receptors
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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G Campiani et al.
Journal of medicinal chemistry, 39(15), 2922-2938 (1996-07-19)
The synthesis and cardiovascular characterization of a series of novel pyrrolo[2,1-d][1,5]-benzothiazepine derivatives (54-68) are described. Selective peripheral-type benzodiazepine receptor (PBR) ligands, such as PK 11195 and Ro 5-4864, have recently been found to possess low but significant inhibitory activity of
V Nacci et al.
Farmaco (Societa chimica italiana : 1989), 45(5), 545-558 (1990-05-01)
6-p-Methoxyphenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one (IV), cis-7-acetoxy-6,7-dihydro-6-p-methoxyphenylpyrrolo[2,1-d] [1,5]benzothiazepine (V) and some significant 7-acyloxy-6-p-methoxyphenylpyrrolo[2,1-d][1,5]benzothiazepines (VI a-g) were synthesized and tested in vitro for inhibition of the specific binding of 3H-Flunitrazepam, 3H-PK 11195, 3H-Muscimol and 3H-(-)Baclofen to central and peripheral benzodiazepine, GABA-A and GABA-B receptors, respectively.
I Fiorini et al.
Journal of medicinal chemistry, 37(10), 1427-1438 (1994-05-13)
A novel class of ligands specific for MBR receptors has been identified: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. The majority of newly synthesized esters 37-64 as well as some intermediate ketones showed micro- or nanomolar affinity for [3H]PK 11195 binding inhibition. A SAR study
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