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M26305

Sigma-Aldrich

N-Methylacetamide

≥99%

Synonym(s):

Acetylmethylamine

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5 G
$37.50
100 G
$47.20
500 G
$87.90

About This Item

Linear Formula:
CH3CONHCH3
CAS Number:
79-16-3
Molecular Weight:
73.09
Beilstein/REAXYS Number:
1071255
EC Number:
201-182-6
MDL number:
MFCD00008683
UNSPSC Code:
12352100
PubChem Substance ID:
24896748
NACRES:
NA.22

$37.50

Available to ship onApril 03, 2025Details

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assay

≥99%

refractive index

n20/D 1.433 (lit.)

bp

204-206 °C (lit.)

mp

26-28 °C (lit.)

density

0.957 g/mL at 25 °C (lit.)

SMILES string

CNC(C)=O

InChI

1S/C3H7NO/c1-3(5)4-2/h1-2H3,(H,4,5)

Inchi Key

OHLUUHNLEMFGTQ-UHFFFAOYSA-N

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Application

N-Methylacetamide can be used:
  • To synthesize N-methyl-N-(3-thienyl)acetamide by reacting with 3-bromothiophene in the presence of CuI catalyst and N,N′-dimethylethylenediamine.(1)
  • As a ligand to synthesize the zirconium(IV) complex, Zr(MeC(O)NMe)4 by reacting with tetrakis(dimethylamido)zirconium.(2)

Pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

240.8 °F

flash_point_c

116 °C

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9334
STBL4405
BCCM6518
STBL3758
STBL0761

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Michael Harder et al.
ChemMedChem, 8(3), 397-404 (2013-01-29)
The less polar π-surface of protein amide groups is exposed in many receptor binding sites, either as part of the backbone or in Gln/Asn side chains. Using quantum chemical calculations and Protein Data Bank (PDB) searches on model systems, we
Aneta Buczek et al.
Journal of molecular modeling, 18(6), 2471-2478 (2011-10-22)
A linear correlation between harmonic and anharmonic frequencies of water calculated at B3LYP level of theory was observed with a number of basis sets. Similar relationships were found in both the gas phase and solution for several small molecules. The
Arend G Dijkstra et al.
The journal of physical chemistry. B, 115(18), 5392-5401 (2011-01-07)
The amide vibrational modes play an important role in energy transport and relaxation in polypeptides and proteins and provide us with spectral markers for structure and structural dynamics of these macromolecules. Here, we present a detailed model to describe the
Hangfei Chen et al.
Environmental science & technology, 51(20), 11710-11717 (2017-09-15)
Amides represent an important class of nitrogen-containing compounds in the atmosphere that can in theory interact with atmospheric acidic particles and contribute to secondary aerosol formation. In this study, uptake coefficients (γ) of six alkylamides (C
Weifeng Li et al.
The journal of physical chemistry. B, 116(4), 1446-1451 (2012-01-06)
The mechanism of urea-induced protein denaturation is explored through studying the salting effect of urea on 14 amino acid side chain analogues, and N-methylacetamide (NMA) which mimics the protein backbone. The solvation free energies of the 15 molecules were calculated
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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