Drug metabolism and disposition: the biological fate of chemicals, 16(1), 85-92 (1988-01-01)
gamma-Glutamyl-beta-(S-tetrahydrothiophenium)alanyl-glycine, the glutathione-sulfonium conjugate of busulfan and 1,4-diiodobutane, was identified in the bile of rats following intravenous administration of equimolar doses of either compound. The glutathione-sulfonium conjugate was synthesized from 1-bromo-4-chlorobutane and characterized by 1H and 13C NMR and FAB/MS.
Biochemical and biophysical research communications, 128(1), 360-367 (1985-04-16)
Rat liver glutathione S-transferases catalyzed the conjugation of 1,4-diiodobutane with glutathione in vitro. The reaction followed saturation kinetics and was dependent on the concentration of the enzyme, substrate and glutathione in the incubation media. S-Benzylglutathione inhibited the enzymatic conversion of
In comparison with pristine sinomenine and carborane precursors, the calculations of molecular docking with matrix metalloproteinases (MMPs) and methylcarboranyl-n-butyl sinomenine showed improved interactions. Accordingly, methylcarboranyl-n-butyl sinomenine shows a high potential in the treatment of rheumatoid arthritis (RA) in the presence
Responsive polymer-based sensors have attracted considerable attention due to their ability to detect the presence of analytes and convert the detected signal into a physical and/or chemical change. High responsiveness, fast response speed, good linearity, strong stability, and small hysteresis
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