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C4790

Sigma-Aldrich

Carbenoxolone disodium salt

≥98%

Synonym(s):

3β-Hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate

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About This Item

Linear Formula:
C34H48O7Na2
CAS Number:
Molecular Weight:
614.72
EC Number:
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22

assay

≥98%

form

powder

storage temp.

2-8°C

SMILES string

[Na].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)[C@]4([H])[C@@]5(C)CC[C@H](OC(=O)CCC(O)=O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23?,24-,27+,30+,31?,32-,33+,34+;;/m0../s1

InChI key

BQENDLAVTKRQMS-FDPMUVMVSA-L

General description

Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

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Promotion of nasal absorption of insulin by glycyrrhetinic acid derivatives. I.
Mishima M, et al.
Journal of Pharmacobio-Dynamics, 12(1), 31-36 (1989)
Seo-Yeon Yoon et al.
The journal of pain : official journal of the American Pain Society, 14(2), 205-214 (2013-02-05)
Spinal glial cells contribute to the development of many types of inflammatory and neuropathic pain. Here the contribution of spinal astrocytes and astrocyte gap junctions to oxaliplatin-induced mechanical hypersensitivity was explored. The expression of glial fibrillary acidic protein (GFAP) in
Atsushi Sengiku et al.
Scientific reports, 8(1), 1996-1996 (2018-02-02)
Day-night changes in the storage capacity of the urinary bladder are indispensable for sound sleep. Connexin 43 (Cx43), a major gap junction protein, forms hemichannels as a pathway of ATP in other cell types, and the urinary bladder utilizes ATP
R A Warwick et al.
European journal of pain (London, England), 17(4), 571-580 (2012-10-16)
Chemotherapy-induced peripheral neuropathy is a serious side effect in cancer treatment, a major manifestation being neuropathic pain that can be debilitating and can reduce the quality of life of the patient. Oxaliplatin and taxol are common anti-cancer drugs that induce
Clint Gray et al.
PloS one, 8(1), e53505-e53505 (2013-01-12)
Maternal undernutrition results in elevated blood pressure (BP) and endothelial dysfunction in adult offspring. However, few studies have investigated interventions during early life to ameliorate the programming of hypertension and vascular disorders. We have utilised a model of maternal undernutrition

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