B62404

1-Bromo-3-chloropropane

99%

• Synonym(s): I-BCP, Trimethylene bromochloride, Trimethylene chlorobromide
• Linear Formula: Cl(CH₂)₃Br
• CAS Number: 109-70-6
• Molecular Weight: 157.44
• Beilstein/REAXYS Number: 605278
• EC Number: 203-697-1
• MDL number: MFCD00000998
• UNSPSC Code: 12352100
• PubChem Substance ID: 24891900
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 99%
• form: liquid
• refractive index: n20/D 1.486 (lit.)
• bp: 144-145 °C (lit.)
• density: 1.592 g/mL at 25 °C (lit.)
• SMILES string: ClCCCBr
• InChI: 1S/C3H6BrCl/c4-2-1-3-5/h1-3H2
• InChI key: MFESCIUQSIBMSM-UHFFFAOYSA-N

Description

Application

1-Bromo-3-chloropropane is generally used as C₃ linker/spacer in a wide range of molecules including medicinally important compounds. Some of the examples are:

• Synthesis of polymer nanoparticles (NPs) to deliver doxorubicin, camptothecin, and cisplatin.
• Synthesis of antiprion active acridine derivatives for prion infection.
• Total synthesis of aspidospermine, aspidospermidine, and quebrachamine and (±)-crispine A.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H331,H335,H341,H412
• pcodes: P202 - P261 - P273 - P301 + P312 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Muta. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter