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574740

Sigma-Aldrich

trans-Diamminetetrachloroplatinum(IV)

≥99.9% trace metals basis

Synonym(s):

trans- Tetrachlorodiammineplatinum

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About This Item

Linear Formula:
Pt(NH3)2Cl4
CAS Number:
16893-06-4
Molecular Weight:
370.95
MDL number:
MFCD00050045
UNSPSC Code:
12352302
PubChem Substance ID:
329758311
NACRES:
NA.23

assay

≥99.9% trace metals basis

form

powder

mp

>300 °C (lit.)

SMILES string

N.N.Cl[Pt](Cl)(Cl)Cl

InChI

1S/4ClH.2H3N.Pt/h4*1H;2*1H3;/q;;;;;;+4/p-4

InChI key

RBHOYUZKIANPPG-UHFFFAOYSA-J

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Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
03205JA

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M Defais et al.
Chemico-biological interactions, 74(3), 343-352 (1990-01-01)
DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which was detected by a rapid bacterial assay. In addition
A C Plooy et al.
Cancer research, 44(5), 2043-2051 (1984-05-01)
Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV)] are known to possess antitumor activity, whereas the two trans-stereoisomers [trans-diamminedichloroplatinum(II) and trans-diamminetetrachloroplatinum(IV)] are inactive. When the effects
H Razaka et al.
Chemico-biological interactions, 60(2), 207-215 (1986-11-01)
After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magnitude greater than DDP. However, at identical intracellular drug concentrations, the Pt(IV) compound formed only half as many

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