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55708

Sigma-Aldrich

4-Hydroxymethyl-3-methoxyphenoxyacetic acid

≥97.0%

Synonym(s):

HMPA

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About This Item

Empirical Formula (Hill Notation):
C10H12O5
CAS Number:
83590-77-6
Molecular Weight:
212.20
Beilstein/REAXYS Number:
5029802
MDL number:
MFCD00134896
UNSPSC Code:
12352200
PubChem Substance ID:
57651504

assay

≥97.0%

reaction suitability

reagent type: cross-linking reagent

mp

~95 °C (dec.)

SMILES string

COc1cc(OCC(O)=O)ccc1CO

InChI

1S/C10H12O5/c1-14-9-4-8(15-6-10(12)13)3-2-7(9)5-11/h2-4,11H,5-6H2,1H3,(H,12,13)

InChI key

ZKDXHLFLKKWCBY-UHFFFAOYSA-N

Other Notes

Linker used in solid-phase peptide synthesis[1]
Sales restrictions may apply

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
1409222
404528/1
429292/1
360969/1

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R.C. Sheppard et al.
Journal of the Chemical Society. Chemical Communications, 587-587 (1982)
R C Sheppard et al.
International journal of peptide and protein research, 20(5), 451-454 (1982-11-01)
Details are given of the preparation of two acid-labile peptide-resin linkage agents for use in solid phase peptide synthesis, viz. 4-hydroxymethylphenoxy-acetic acid and 3-methoxy-4-hydroxymethylphenoxyacetic acid. The latter is suitable for the preparation of peptide fragments bearing t-butyl-based side chain protecting

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